# An Efficacy and Safety Study of Lanabecestat (LY3314814) in Early Alzheimer's Disease

Clinical trial · AstraZeneca

- Archive id: nct:NCT02245737
- Published: 2014-09-22
- Venue: ClinicalTrials.gov
- ClinicalTrials.gov: https://clinicaltrials.gov/study/NCT02245737
- Source URL: https://clinicaltrials.gov/study/NCT02245737
- Provenance: clinicaltrials

## Abstract

The purpose of this study is to assess the efficacy and safety of lanabecestat compared with placebo administered for 104 weeks in the treatment of early Alzheimer´s disease. The study will test the hypothesis that lanabecestat is a disease-modifying treatment for participants with early Alzheimer´s disease, defined as the continuum of participants with mild cognitive impairment (MCI) due to Alzheimer´s disease and participants diagnosed with mild dementia of the Alzheimer´s type, as measured by change from baseline on the 13-item Alzheimer's Disease Assessment Scale - Cognitive Subscale (ADAS-Cog13) score at week 104 in each of the 2 lanabecestat treatment groups compared with placebo.

_Abstract reproduced under ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters._

## Trial details

- acronym: AMARANTH
- status: TERMINATED
- phase: PHASE2, PHASE3
- study type: INTERVENTIONAL
- enrollment: 2218
- sponsor: AstraZeneca
- conditions: Alzheimer´s Disease
- interventions: DRUG: Lanabecestat; DRUG: Placebo
- start date: 2014-09-30
- start date type: ACTUAL
- primary completion date: 2018-10-04
- has results: true
- data source: ClinicalTrials.gov
- data processed: 2026-10-29T09:00:05
- modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters

Topics: [Alzheimer's, Parkinson's & Neurodegeneration](https://space-kitty.com/topics/neurodegeneration)

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