# A Study of Intranasal Esketamine Plus an Oral Antidepressant for Relapse Prevention in Adult Participants With Treatment-resistant Depression

Clinical trial · Janssen Research & Development, LLC

- Archive id: nct:NCT02493868
- Published: 2015-07-10
- Venue: ClinicalTrials.gov
- ClinicalTrials.gov: https://clinicaltrials.gov/study/NCT02493868
- Source URL: https://clinicaltrials.gov/study/NCT02493868
- Provenance: clinicaltrials

## Abstract

The purpose of this study is to assess the efficacy of intranasal esketamine plus an oral antidepressant compared with an oral antidepressant (active comparator) plus intranasal placebo in delaying relapse of depressive symptoms in participants with treatment-resistant depression (TRD) who are in stable remission after an induction and optimization course of intranasal esketamine plus an oral antidepressant.

_Abstract reproduced under ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters._

## Trial details

- acronym: SUSTAIN-1
- status: COMPLETED
- phase: PHASE3
- study type: INTERVENTIONAL
- enrollment: 719
- sponsor: Janssen Research & Development, LLC
- conditions: Depressive Disorder, Treatment-Resistant
- interventions: DRUG: Esketamine; DRUG: Placebo; DRUG: Duloxetine (Oral Antidepressant); DRUG: Escitalopram (Oral antidepressant); DRUG: Sertraline (Oral Antidepressant); DRUG: Venlafaxine Extended Release (XR) (Oral Antidepressant)
- start date: 2015-10-01
- start date type: ACTUAL
- primary completion date: 2018-02-15
- has results: true
- data source: ClinicalTrials.gov
- data processed: 2026-10-29T09:00:05
- modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters

Topics: [Novel Psychiatric Therapeutics](https://space-kitty.com/topics/psychiatric-therapeutics)

Cited in dossiers:
- [Novel Psychiatric Therapeutics: State of the Field (October 2026)](https://space-kitty.com/dossiers/psychiatric-therapeutics)

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