# Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity

Clinical trial · Novo Nordisk A/S

- Archive id: nct:NCT03574597
- Published: 2018-07-02
- Venue: ClinicalTrials.gov
- ClinicalTrials.gov: https://clinicaltrials.gov/study/NCT03574597
- Source URL: https://clinicaltrials.gov/study/NCT03574597
- Provenance: clinicaltrials

## Abstract

The researchers are doing the study to see if semaglutide may reduce the risk of having cardiovascular events in patients with overweight or obesity and with prior cardiovascular disease. The participant will either get semaglutide (active medicine) or placebo ("dummy" medicine). Which treatment the participants get is decided by chance. The participant's chance of getting semaglutide or placebo is the same. The participant will get the study medicine in a pen. The participants will need to use the pen to inject the study medicine in a skinfold once a week. The study will last for about 2.5 to 5 years. Participants will have up to 25 clinic visits with the study doctor.

_Abstract reproduced under ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters._

## Trial details

- acronym: SELECT
- status: COMPLETED
- phase: PHASE3
- study type: INTERVENTIONAL
- enrollment: 17604
- sponsor: Novo Nordisk A/S
- conditions: Overweight; Obesity
- interventions: DRUG: Semaglutide; DRUG: Placebo (semaglutide)
- start date: 2018-10-24
- start date type: ACTUAL
- primary completion date: 2023-06-21
- has results: true
- data source: ClinicalTrials.gov
- data processed: 2026-10-29T09:00:05
- modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters

Topics: [GLP-1 & Incretin Therapies](https://space-kitty.com/topics/glp1-metabolic)

---
Space Kitty Archive · https://space-kitty.com · API: https://space-kitty.com/api/v1 · MCP: https://space-kitty.com/mcp · Premium: $0.20/request via x402 (Base Sepolia (testnet)). Metadata: arXiv (CC0), OpenAlex (CC0), Europe PMC (CC BY/CC0 works), ClinicalTrials.gov.