# A Study to Compare Different Antibiotics and Different Modes of Fluid Treatment for Children With Severe Pneumonia

Clinical trial · University of Oxford

- Archive id: nct:NCT04041791
- Published: 2019-08-01
- Venue: ClinicalTrials.gov
- ClinicalTrials.gov: https://clinicaltrials.gov/study/NCT04041791
- Source URL: https://clinicaltrials.gov/study/NCT04041791
- Provenance: clinicaltrials

## Abstract

Pneumonia is one of the top causes of death in children aged below 5. More than 10% of children with severe pneumonia die. We are not sure that the currently recommended antibiotics used in children with pneumonia are the most effective. No studies have been carried out to find out whether children with pneumonia should be given intravenous (IV) fluids or nasogastric (NG) feeds. The SEARCH trial aims to find out which antibiotics and modes of feeding are the most effective in treating children with severe pneumonia and therefore helping reduce mortality.

_Abstract reproduced under ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters._

## Trial details

- acronym: SEARCH
- status: COMPLETED
- phase: PHASE3
- study type: INTERVENTIONAL
- enrollment: 4392
- sponsor: University of Oxford
- conditions: Pneumonia
- interventions: DRUG: Benzyl penicillin; DRUG: Gentamicin Sulfate; DRUG: Ceftriaxone; DRUG: Amoxicillin Clavulanate; OTHER: Intravenous fluid; OTHER: Nasogastric feeds; DRUG: Ampicillin
- start date: 2019-08-19
- start date type: ACTUAL
- primary completion date: 2024-04-05
- has results: false
- data source: ClinicalTrials.gov
- data processed: 2026-10-29T09:00:05
- modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters

Topics: [Infectious Disease, Vaccines & Antimicrobial Resistance](https://space-kitty.com/topics/infectious-disease-amr)

Cited in dossiers:
- [Infectious Disease, Vaccines & Antimicrobial Resistance: State of the Field (October 2026)](https://space-kitty.com/dossiers/infectious-disease-amr)

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