# Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis

Clinical trial · Children's Hospital of Philadelphia

- Archive id: nct:NCT04102371
- Published: 2019-09-25
- Venue: ClinicalTrials.gov
- ClinicalTrials.gov: https://clinicaltrials.gov/study/NCT04102371
- Source URL: https://clinicaltrials.gov/study/NCT04102371
- Provenance: clinicaltrials

## Abstract

The objectives of this multicenter pragmatic clinical trial are to compare the effectiveness and relative safety of balanced fluid resuscitation versus 0.9% "normal" saline in children with septic shock, including whether balanced fluid resuscitation can reduce progression of kidney injury.

_Abstract reproduced under ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters._

## Trial details

- acronym: PRoMPT BOLUS
- status: COMPLETED
- phase: PHASE3
- study type: INTERVENTIONAL
- enrollment: 9041
- sponsor: Children's Hospital of Philadelphia
- conditions: Shock; Septic
- interventions: DRUG: Lactated Ringer; DRUG: Normal Saline; DRUG: Plasma-lyte
- start date: 2020-08-25
- start date type: ACTUAL
- primary completion date: 2025-12-01
- has results: false
- data source: ClinicalTrials.gov
- data processed: 2026-10-29T09:00:05
- modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters

Topics: [Infectious Disease, Vaccines & Antimicrobial Resistance](https://space-kitty.com/topics/infectious-disease-amr)

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