# A Long-term Comparison of Esketamine Nasal Spray Versus Quetiapine Extended Release, Both in Combination With a Selective Serotonin Reuptake Inhibitor/Serotonin-Norepinephrine Reuptake Inhibitor, in Participants With Treatment Resistant Major Depressive Disorder

Clinical trial · Janssen-Cilag International NV

- Archive id: nct:NCT04338321
- Published: 2020-04-08
- Venue: ClinicalTrials.gov
- ClinicalTrials.gov: https://clinicaltrials.gov/study/NCT04338321
- Source URL: https://clinicaltrials.gov/study/NCT04338321
- Provenance: clinicaltrials

## Abstract

The primary purpose of this study is to evaluate the efficacy of flexibly dosed esketamine nasal spray compared with quetiapine extended-release (XR), both in combination with a continuing selective serotonin reuptake inhibitor/serotonin-norepinephrine reuptake inhibitor (SSRI/SNRI), in achieving remission in participants who have treatment-resistant major depressive disorder (MDD) with a current moderate to severe depressive episode.

_Abstract reproduced under ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters._

## Trial details

- acronym: ESCAPE-TRD
- status: COMPLETED
- phase: PHASE3
- study type: INTERVENTIONAL
- enrollment: 676
- sponsor: Janssen-Cilag International NV
- conditions: Depressive Disorder, Major
- interventions: DRUG: Esketamine 28 mg; DRUG: Esketamine 56 mg; DRUG: Esketamine 84 mg; DRUG: Quetiapine XR 50 mg; DRUG: Quetiapine XR 100 mg; DRUG: Quetiapine XR 150 mg; DRUG: SSRI/SNRI
- start date: 2020-08-21
- start date type: ACTUAL
- primary completion date: 2022-01-20
- has results: true
- data source: ClinicalTrials.gov
- data processed: 2026-10-29T09:00:05
- modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters

Topics: [Novel Psychiatric Therapeutics](https://space-kitty.com/topics/psychiatric-therapeutics)

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