# Esketamine and Perioperative Depressive Symptoms

Clinical trial · Beijing Tiantan Hospital

- Archive id: nct:NCT04425473
- Published: 2020-06-11
- Venue: ClinicalTrials.gov
- ClinicalTrials.gov: https://clinicaltrials.gov/study/NCT04425473
- Source URL: https://clinicaltrials.gov/study/NCT04425473
- Provenance: clinicaltrials

## Abstract

Perioperative depressive symptoms (PDS) are common in population undergoing surgery, and this would be sharpened especially for complicated, high-risk major surgery. However, None of treatments could resolve this clinical problem during limited perioperative period. The remarkable effects of ketamine on treatment resistant depression have been verified by several clinical trials and the enantiomer S-ketamine (esketamine) showed similar antidepressant efficacy with better safety in recent studies. The efficacy and safety of esketamine administrated intra-operatively for PDS will be verified in this study. Other secondary outcomes such as anxiety, postoperative pain and psychiatric symptoms will also be investigated.

_Abstract reproduced under ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters._

## Trial details

- status: COMPLETED
- phase: PHASE2, PHASE3
- study type: INTERVENTIONAL
- enrollment: 435
- sponsor: Beijing Tiantan Hospital
- conditions: Depressive Symptoms; Esketamine; Perioperative Complication; Major Surgery
- interventions: DRUG: Esketamine; DRUG: Normal saline
- start date: 2021-02-19
- start date type: ACTUAL
- primary completion date: 2024-06-23
- has results: false
- data source: ClinicalTrials.gov
- data processed: 2026-10-29T09:00:05
- modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters

Topics: [Novel Psychiatric Therapeutics](https://space-kitty.com/topics/psychiatric-therapeutics)

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