# Multi-CAR-T Cells Targeting B Cell Lymphomas

Clinical trial · Shenzhen Geno-Immune Medical Institute

- Archive id: nct:NCT04429438
- Published: 2020-06-12
- Venue: ClinicalTrials.gov
- ClinicalTrials.gov: https://clinicaltrials.gov/study/NCT04429438
- Source URL: https://clinicaltrials.gov/study/NCT04429438
- Provenance: clinicaltrials

## Abstract

This study aims to evaluate safety and efficacy of a combination of 4th generation chimeric antigen receptor gene-modified T cells targeting B cell surface molecules including CD19 and alternative CARTs as booster and consolidation treatment for patients with highly resistant B cell lymphomas, including primary mediastinal B cell lymphoma (PMBCL) and BCL involving central nervous system (CNS-BCL). Clinical response and development of a simplified and standardized lentiviral vector and cell production protocol will be investigated. This is a phase I/II trial enrolling patients from multiple clinical centers.

_Abstract reproduced under ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters._

## Trial details

- status: NOT_YET_RECRUITING
- phase: PHASE1, PHASE2
- study type: INTERVENTIONAL
- enrollment: 11
- sponsor: Shenzhen Geno-Immune Medical Institute
- conditions: B Cell Lymphoma (BCL)
- interventions: BIOLOGICAL: 4SCAR19 and 4SCAR20/22/70/PSMA/13/79b/GD2
- start date: 2027-06-01
- start date type: ESTIMATED
- primary completion date: 2029-12-31
- has results: false
- data source: ClinicalTrials.gov
- data processed: 2026-10-29T09:00:05
- modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters

Topics: [Cancer Immunotherapy](https://space-kitty.com/topics/cancer-immunotherapy), [Gene & Cell Therapy](https://space-kitty.com/topics/gene-cell-therapy)

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