# Study in Primary Care Evaluating Inclisiran Delivery Implementation + Enhanced Support

Clinical trial · Novartis Pharmaceuticals

- Archive id: nct:NCT04807400
- Published: 2021-03-19
- Venue: ClinicalTrials.gov
- ClinicalTrials.gov: https://clinicaltrials.gov/study/NCT04807400
- Source URL: https://clinicaltrials.gov/study/NCT04807400
- Provenance: clinicaltrials

## Abstract

The purpose of this study was to evaluate the implementation of inclisiran in a regional primary care setting in the UK Inclisiran, also known as KJX839, is a medication made to reduce the level of "bad" cholesterol (LDL-cholesterol) in the blood. Inclisiran works in a way that makes the liver produce less of a substance called 'PCSK9'. PCSK9 reduces the ability of the liver to remove LDL-cholesterol from the blood. By lowering the production of PCSK9, Inclisiran leads to more LDL-cholesterol being removed by the liver from the blood, thereby reducing LDL-cholesterol overall.

_Abstract reproduced under ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters._

## Trial details

- acronym: SPIRIT
- status: COMPLETED
- phase: PHASE3
- study type: INTERVENTIONAL
- enrollment: 892
- sponsor: Novartis Pharmaceuticals
- conditions: Atherosclerotic Cardiovascular Disease; Atherosclerotic Cardiovascular Disease Risk Equivelents; Elevated Low Density Lipoprotein Cholesterol
- interventions: DRUG: Inclisiran; BEHAVIORAL: Behavioural Support; DRUG: Background lipid lowering therapy
- start date: 2021-07-07
- start date type: ACTUAL
- primary completion date: 2023-01-13
- has results: true
- data source: ClinicalTrials.gov
- data processed: 2026-10-29T09:00:05
- modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters

Topics: [Cardiovascular Therapeutics](https://space-kitty.com/topics/cardiovascular-innovation)

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