# A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers

Clinical trial · Jazz Pharmaceuticals

- Archive id: nct:NCT05152147
- Published: 2021-12-09
- Venue: ClinicalTrials.gov
- ClinicalTrials.gov: https://clinicaltrials.gov/study/NCT05152147
- Source URL: https://clinicaltrials.gov/study/NCT05152147
- Provenance: clinicaltrials

## Abstract

This study is being done to find out if zanidatamab, when given with chemotherapy plus or minus tislelizumab, is safe and works better than trastuzumab given with chemotherapy. The patients in this study will have advanced human epidermal growth factor 2 (HER2)-positive stomach and esophageal cancers that are no longer treatable with surgery (unresectable) or chemoradiation, and/or have grown or spread to other parts of the body (metastatic).

_Abstract reproduced under ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters._

## Trial details

- acronym: HERIZON-GEA-01
- status: ACTIVE_NOT_RECRUITING
- phase: PHASE3
- study type: INTERVENTIONAL
- enrollment: 920
- sponsor: Jazz Pharmaceuticals
- conditions: Gastric Neoplasms; Gastroesophageal Adenocarcinoma; Esophageal Adenocarcinoma
- interventions: DRUG: Zanidatamab; DRUG: Tislelizumab; DRUG: Trastuzumab; DRUG: Capecitabine; DRUG: Oxaliplatin; DRUG: Cisplatin; DRUG: 5-Fluorouracil
- start date: 2021-12-02
- start date type: ACTUAL
- primary completion date: 2026-07-15
- has results: false
- data source: ClinicalTrials.gov
- data processed: 2026-10-29T09:00:05
- modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters

Topics: [Cancer Immunotherapy](https://space-kitty.com/topics/cancer-immunotherapy)

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