# A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a)

Clinical trial · Eli Lilly and Company

- Archive id: nct:NCT06292013
- Published: 2024-03-04
- Venue: ClinicalTrials.gov
- ClinicalTrials.gov: https://clinicaltrials.gov/study/NCT06292013
- Source URL: https://clinicaltrials.gov/study/NCT06292013
- Provenance: clinicaltrials

## Abstract

The purpose of this study is to evaluate the efficacy of lepodisiran in reducing cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular disease or are at risk of a heart attack or stroke. The study drug will be administered subcutaneously (SC) (under the skin). Approximately 1700 additional participants will be enrolled in an addendum to explore Lp(a) lowering with an alternative dosing schema.

_Abstract reproduced under ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters._

## Trial details

- status: ACTIVE_NOT_RECRUITING
- phase: PHASE3
- study type: INTERVENTIONAL
- enrollment: 17300
- sponsor: Eli Lilly and Company
- conditions: Atherosclerotic Cardiovascular Disease (ASCVD); Elevated Lp(a)
- interventions: DRUG: Lepodisiran Sodium; DRUG: Placebo
- start date: 2024-03-05
- start date type: ACTUAL
- primary completion date: 2029-03-01
- has results: false
- data source: ClinicalTrials.gov
- data processed: 2026-10-29T09:00:05
- modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters

Topics: [Cardiovascular Therapeutics](https://space-kitty.com/topics/cardiovascular-innovation)

Cited in dossiers:
- [Cardiovascular Therapeutics: State of the Field (October 2026)](https://space-kitty.com/dossiers/cardiovascular-innovation)

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