# Combination Immunotherapy Targeting Melanoma

Clinical trial · Shenzhen Geno-Immune Medical Institute

- Archive id: nct:NCT06739226
- Published: 2024-12-18
- Venue: ClinicalTrials.gov
- ClinicalTrials.gov: https://clinicaltrials.gov/study/NCT06739226
- Source URL: https://clinicaltrials.gov/study/NCT06739226
- Provenance: clinicaltrials

## Abstract

The purpose of this study is to assess the feasibility, safety and efficacy of combination immunotherapy based on CAR T cells, cytotoxic T lymphocytes (CTLs), and dendritic cell (DC) vaccines modified with GM-CSF and B7-2 (CD86) against melanoma, which targets CAR T specific surface antigens such as GD2, CTL specific antigens such as MAGE-A4, gp100 and a pool of melanoma specific antigens presented by the DCs. Another goal of the study is to learn more about the function and persistence of the CAR T cells and antigen-specific immune effectors in patients.

_Abstract reproduced under ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters._

## Trial details

- status: NOT_YET_RECRUITING
- phase: PHASE1, PHASE2
- study type: INTERVENTIONAL
- enrollment: 30
- sponsor: Shenzhen Geno-Immune Medical Institute
- conditions: Melanoma
- interventions: BIOLOGICAL: Antigen-specific CAR T, CTL and DCvac to treat melanoma.
- start date: 2027-06-30
- start date type: ESTIMATED
- primary completion date: 2028-12-31
- has results: false
- data source: ClinicalTrials.gov
- data processed: 2026-10-29T09:00:05
- modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters

Topics: [Cancer Immunotherapy](https://space-kitty.com/topics/cancer-immunotherapy)

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