# A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

Clinical trial · Cybin IRL Limited

- Archive id: nct:NCT06793397
- Published: 2025-01-27
- Venue: ClinicalTrials.gov
- ClinicalTrials.gov: https://clinicaltrials.gov/study/NCT06793397
- Source URL: https://clinicaltrials.gov/study/NCT06793397
- Provenance: clinicaltrials

## Abstract

The purpose of this study is to determine the efficacy, safety and tolerability of CYB003 compared to matching placebo as adjunctive treatment in patients with MDD. For more information about the EMBRACE study, including participating study locations, and to register your interest in learning more about participation, please visit the study website: https://embrace-mdd-trial.com/

_Abstract reproduced under ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters._

## Trial details

- acronym: EMBRACE
- status: RECRUITING
- phase: PHASE3
- study type: INTERVENTIONAL
- enrollment: 330
- sponsor: Cybin IRL Limited
- conditions: Major Depressive Disorder (MDD); Depression in Adults; Depression - Major Depressive Disorder; Depression Disorders; Depression Disorder; Depression
- interventions: DRUG: CYB003; BEHAVIORAL: Psychological Support
- start date: 2025-12-10
- start date type: ACTUAL
- primary completion date: 2027-06-07
- has results: false
- data source: ClinicalTrials.gov
- data processed: 2026-10-29T09:00:05
- modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters

Topics: [Novel Psychiatric Therapeutics](https://space-kitty.com/topics/psychiatric-therapeutics)

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