# Psilocybin-assisted Therapy for Post-Traumatic Stress Disorder in Survivors of Intimate Partner Violence

Clinical trial · University of Calgary

- Archive id: nct:NCT06885996
- Published: 2025-03-20
- Venue: ClinicalTrials.gov
- ClinicalTrials.gov: https://clinicaltrials.gov/study/NCT06885996
- Source URL: https://clinicaltrials.gov/study/NCT06885996
- Provenance: clinicaltrials

## Abstract

The goal of this randomized controlled trial is to evaluate the efficacy of psilocybin administered with Acceptance and Commitment Therapy (ACT) as an intervention to reduce post-traumatic stress disorder (PTSD) symptom burden in adult (aged 18-65) survivors of intimate partner violence (IPV). This trail will test the following 2 aims: AIM 1 : To compare the efficacy of a therapeutic psilocybin dose at improving outcomes on the PCL-5 and CAPS-5 as compared to an active control psilocybin dose in IPV survivors with chronic PTSD. AIM 2: To evaluate the efficacy of psilocybin on quality of life, cognitive function, motor ability, depression, anxiety, and cognitive flexibility. Participants will be asked to: \* Complete a 2 part screening process \* Attend a baseline assessment \* Complete a psychoeducation preparation session(s) \* Attend psilocybin administration session (receive high dose \\\[25mg\\\] or low dose psilocybin \\\[1mg\\\]) \* Complete 5-6 weekly sessions of ACT \* Repeat outcome measures at 1-week, 4 weeks, 3 months (online questionnaires only), and 6 months post-psilocybin administration.

_Abstract reproduced under ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters._

## Trial details

- acronym: PsiPTSD
- status: NOT_YET_RECRUITING
- phase: PHASE2
- study type: INTERVENTIONAL
- enrollment: 76
- sponsor: University of Calgary
- conditions: Post Traumatic Stress Disorder PTSD; Intimate Partner Violence (IPV)
- interventions: DRUG: Psilocybin
- start date: 2026-10-01
- start date type: ESTIMATED
- primary completion date: 2028-08-01
- has results: false
- data source: ClinicalTrials.gov
- data processed: 2026-10-29T09:00:05
- modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters

Topics: [Novel Psychiatric Therapeutics](https://space-kitty.com/topics/psychiatric-therapeutics)

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