# A Study to Evaluate Safety and Efficacy of KarXT + KarX-EC as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-5)

Clinical trial · Bristol-Myers Squibb

- Archive id: nct:NCT06947941
- Published: 2025-04-27
- Venue: ClinicalTrials.gov
- ClinicalTrials.gov: https://clinicaltrials.gov/study/NCT06947941
- Source URL: https://clinicaltrials.gov/study/NCT06947941
- Provenance: clinicaltrials

## Abstract

The purpose of this study is to evaluate KarXT + KarX-EC as a treatment for psychosis associated with Alzheimer's disease.

_Abstract reproduced under ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters._

## Trial details

- status: RECRUITING
- phase: PHASE3
- study type: INTERVENTIONAL
- enrollment: 325
- sponsor: Bristol-Myers Squibb
- conditions: Alzheimer Disease; Psychosis
- interventions: DRUG: KarXT; DRUG: KarX-EC; DRUG: KarXT + KarX-EC Arm Matching Placebo
- start date: 2026-03-25
- start date type: ACTUAL
- primary completion date: 2028-02-21
- has results: false
- data source: ClinicalTrials.gov
- data processed: 2026-10-29T09:00:05
- modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters

Topics: [Novel Psychiatric Therapeutics](https://space-kitty.com/topics/psychiatric-therapeutics)

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