# Mindfulness-based Psilocybin Therapy for PTSD

Clinical trial · Anthony P King

- Archive id: nct:NCT07104916
- Published: 2025-08-05
- Venue: ClinicalTrials.gov
- ClinicalTrials.gov: https://clinicaltrials.gov/study/NCT07104916
- Source URL: https://clinicaltrials.gov/study/NCT07104916
- Provenance: clinicaltrials

## Abstract

The goal of this study is to learn how psilocybin delivered with mindfulness-based therapy may help symptoms of posttraumatic stress disorder (PTSD). This is an assessor-blinded, randomized, controlled study in participants with PTSD. The study will investigate the changes in brain activity, connectivity, and microstructural neuroplasticity assessed using EEG/EMG and multimodal MRI measures after administration of one oral dose of psilocybin, accompanied either with standard "psychological support" only; or with standard support plus Mindfulness-based Cognitive Therapy (MBCT).

_Abstract reproduced under ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters._

## Trial details

- status: RECRUITING
- phase: PHASE2
- study type: INTERVENTIONAL
- enrollment: 30
- sponsor: Anthony P King
- conditions: Post Traumatic Stress Disorder; Depression - Major Depressive Disorder
- interventions: COMBINATION_PRODUCT: Psilocybin + MBCT therapy; COMBINATION_PRODUCT: Active Comparator: Psilocybin with Support Only
- start date: 2026-09-01
- start date type: ACTUAL
- primary completion date: 2029-09-01
- has results: false
- data source: ClinicalTrials.gov
- data processed: 2026-10-29T09:00:05
- modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters

Topics: [Novel Psychiatric Therapeutics](https://space-kitty.com/topics/psychiatric-therapeutics)

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