# A Study to Evaluate the Pharmacodynamics of a Combination of QCZ484 and Inclisiran in Participants With Hypertension and Concomitant Hypercholesterolemia

Clinical trial · Novartis Pharmaceuticals

- Archive id: nct:NCT07610278
- Published: 2026-05-27
- Venue: ClinicalTrials.gov
- ClinicalTrials.gov: https://clinicaltrials.gov/study/NCT07610278
- Source URL: https://clinicaltrials.gov/study/NCT07610278
- Provenance: clinicaltrials

## Abstract

This is a multicenter, randomized, double-blind, factorial design Phase 2 study to evaluate the pharmacodynamics, safety and tolerability of a combination of QCZ484 and inclisiran compared to QCZ484, inclisiran, and placebo in participants with hypertension and concomitant hypercholesterolemia.

_Abstract reproduced under ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters._

## Trial details

- status: RECRUITING
- phase: PHASE2
- study type: INTERVENTIONAL
- enrollment: 120
- sponsor: Novartis Pharmaceuticals
- conditions: Hypercholesterolaemia
- interventions: DRUG: QCZ484; DRUG: Inclisiran; DRUG: QCZ484 placebo; DRUG: Inclisiran placebo
- start date: 2026-05-29
- start date type: ACTUAL
- primary completion date: 2027-04-28
- has results: false
- data source: ClinicalTrials.gov
- data processed: 2026-10-29T09:00:05
- modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters

Topics: [Cardiovascular Therapeutics](https://space-kitty.com/topics/cardiovascular-innovation)

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