# Phase 3 Clinical Study Evaluating Efficacy, Safety, and Tolerability of Obicetrapib Vs Bempedoic Acid to Treat Dyslipidemia in Adults With Primary Non-familial Hypercholesterolemia or Mixed Dyslipidemia at High to Very High Cardiovascular Risk, During a Treatment Period of Approximately 84 Days

Clinical trial · A. Menarini International Licensing S.A.

- Archive id: nct:NCT07614958
- Published: 2026-05-29
- Venue: ClinicalTrials.gov
- ClinicalTrials.gov: https://clinicaltrials.gov/study/NCT07614958
- Source URL: https://clinicaltrials.gov/study/NCT07614958
- Provenance: clinicaltrials

## Abstract

This Phase 3, randomized, double-blind, active-controlled study evaluates the efficacy and safety of obicetrapib (OBI) compared to bempedoic acid (BPA) in participants with dyslipidemia at high or very high cardiovascular risk. Participants must have elevated low density lipoprotein cholesterol (LDL-C) levels despite receiving maximally tolerated lipid lowering therapy. The primary objective is to compare the LDL-C lowering effect of OBI (a CETP inhibitor) against BPA at 12 weeks

_Abstract reproduced under ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters._

## Trial details

- acronym: MEDICI
- status: RECRUITING
- phase: PHASE3
- study type: INTERVENTIONAL
- enrollment: 426
- sponsor: A. Menarini International Licensing S.A.
- conditions: Mixed Dyslipidemia; Hypercholesterolaemia
- interventions: DRUG: Obicetrapib 10 mg/Bempedoic Acid Placebo; DRUG: Bempedoic Acid 180mg/Placebo Obicetrapib
- start date: 2026-05-06
- start date type: ACTUAL
- primary completion date: 2027-01-01
- has results: false
- data source: ClinicalTrials.gov
- data processed: 2026-10-29T09:00:05
- modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters

Topics: [Cardiovascular Therapeutics](https://space-kitty.com/topics/cardiovascular-innovation)

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