# Clinical Trial of MDMA-Assisted Therapy for Military Service Members With Posttraumatic Stress Disorder

Clinical trial · U.S. Army Medical Research and Development Command

- Archive id: nct:NCT07704762
- Published: 2026-07-15
- Venue: ClinicalTrials.gov
- ClinicalTrials.gov: https://clinicaltrials.gov/study/NCT07704762
- Source URL: https://clinicaltrials.gov/study/NCT07704762
- Provenance: clinicaltrials

## Abstract

This study is a Phase 2, randomized, double-blind, active-controlled, two-arm, single-site clinical trial designed to evaluate the safety, tolerability, and feasibility of MDMA-Assisted Therapy (MDMA-AT) for Service Members (Active Duty, Guard, or Reserve) diagnosed with moderate-to-severe Post-Traumatic Stress Disorder (PTSD) within a Military Health System (MHS) setting. The trial incorporates Acceptance and Commitment Therapy (ACT) as a core therapeutic modality. Participants will receive MDMA-AT utilizing either full-dose or active-control low-dose MDMA. The trial will also assess a regional referral center model by recruiting participants locally from the National Capital Region and non-locally across the MHS.

_Abstract reproduced under ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters._

## Trial details

- status: NOT_YET_RECRUITING
- phase: PHASE2
- study type: INTERVENTIONAL
- enrollment: 86
- sponsor: U.S. Army Medical Research and Development Command
- conditions: PTSD; Post Traumatic Stress Disorder PTSD; Post Traumatic Stress Disorder
- interventions: DRUG: TREATMENT ARM: Full dose; DRUG: CONTROL ARM: Active-controlled
- start date: 2026-10-01
- start date type: ESTIMATED
- primary completion date: 2028-01-01
- has results: false
- data source: ClinicalTrials.gov
- data processed: 2026-10-29T09:00:05
- modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters

Topics: [Novel Psychiatric Therapeutics](https://space-kitty.com/topics/psychiatric-therapeutics)

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