# A Study of Esketamine Nasal Spray Versus Placebo Spray in Adult Participants With Treatment-resistant Depression

Clinical trial · Janssen Research & Development, LLC

- Archive id: nct:NCT07716098
- Published: 2026-07-21
- Venue: ClinicalTrials.gov
- ClinicalTrials.gov: https://clinicaltrials.gov/study/NCT07716098
- Source URL: https://clinicaltrials.gov/study/NCT07716098
- Provenance: clinicaltrials

## Abstract

The purpose of this study is to evaluate how well each individual dose of esketamine (56 milligrams \\\[mg\\\] and 84 mg) works when compared with placebo in improving depressive symptoms in participants with treatment resistant depression (individuals with major depressive disorder \\\[MDD\\\] who have not responded to at least 2 different antidepressant treatments given at an adequate dose for an adequate duration in the current episode of depression).

_Abstract reproduced under ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters._

## Trial details

- status: RECRUITING
- phase: PHASE3
- study type: INTERVENTIONAL
- enrollment: 348
- sponsor: Janssen Research & Development, LLC
- conditions: Depressive Disorder, Treatment-Resistant
- interventions: DRUG: Esketamine 56 mg; DRUG: Esketamine 84 mg; DRUG: Placebo
- start date: 2026-07-23
- start date type: ACTUAL
- primary completion date: 2028-12-27
- has results: false
- data source: ClinicalTrials.gov
- data processed: 2026-10-29T09:00:05
- modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters

Topics: [Novel Psychiatric Therapeutics](https://space-kitty.com/topics/psychiatric-therapeutics)

Cited in dossiers:
- [Novel Psychiatric Therapeutics: State of the Field (October 2026)](https://space-kitty.com/dossiers/psychiatric-therapeutics)

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