# Semaglutide for Low Back Pain

Clinical trial · Washington University School of Medicine

- Archive id: nct:NCT07731256
- Published: 2026-07-28
- Venue: ClinicalTrials.gov
- ClinicalTrials.gov: https://clinicaltrials.gov/study/NCT07731256
- Source URL: https://clinicaltrials.gov/study/NCT07731256
- Provenance: clinicaltrials

## Abstract

Low back pain is the leading cause of disability in the United States, and obesity is a major risk factor for its development. GLP-1 receptor agonists such as Semaglutide have emerged as effective weight loss agents that may also reduce chronic pain through weight reduction and other mechanisms. This randomized, double-blind, placebo-controlled trial will enroll 250 adults with chronic low back pain and obesity, randomized 1:1 to weekly Semaglutide 2.4 mg or placebo for 52 weeks. The primary outcome is change in low back pain severity, with secondary outcomes including pain-related disability and quality of life.

_Abstract reproduced under ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters._

## Trial details

- status: NOT_YET_RECRUITING
- phase: PHASE2
- study type: INTERVENTIONAL
- enrollment: 250
- sponsor: Washington University School of Medicine
- conditions: Lower Back Pain; Obesity (BMI>30); Chronic Lower Back Pain; glp1 Agonist
- interventions: DRUG: Semaglutide (administered by PDS290 pen-injector); DRUG: Placebo (administered by PDS290 pen-injector)
- start date: 2027-02-01
- start date type: ESTIMATED
- primary completion date: 2031-01-01
- has results: false
- data source: ClinicalTrials.gov
- data processed: 2026-10-29T09:00:05
- modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters

Topics: [GLP-1 & Incretin Therapies](https://space-kitty.com/topics/glp1-metabolic)

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