# A Phase 2b Study to Evaluate the Efficacy, Safety, and PK Profiles of TNP-2092 Administered Via IA Injection in PJI Participants

Clinical trial · TenNor Therapeutics (Zhongshan) Limited

- Archive id: nct:NCT07858916
- Published: 2026-10-05
- Venue: ClinicalTrials.gov
- ClinicalTrials.gov: https://clinicaltrials.gov/study/NCT07858916
- Source URL: https://clinicaltrials.gov/study/NCT07858916
- Provenance: clinicaltrials

## Abstract

This is a Phase 2b, randomized, controlled, open-label clinical study evaluating the efficacy, safety, and local PK profiles of TNP-2092 administered via IA injection on a background of antibiotic treatment in participants with early postoperative (within 3 months after index arthroplasty) or acute hematogenous (within 4 weeks of infection) PJI after knee arthroplasty, without debridement, and in participants with chronic PJI (including PJI occurring after various joint arthroplasties and revision arthroplasties) requiring long-term antibiotic suppressive treatment.

_Abstract reproduced under ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters._

## Trial details

- status: RECRUITING
- phase: PHASE2
- study type: INTERVENTIONAL
- enrollment: 40
- sponsor: TenNor Therapeutics (Zhongshan) Limited
- conditions: Prosthetic Joint Infection (PJI)
- interventions: DRUG: TNP-2092 for injection; DRUG: Vancomycin Hydrochloride for Injection; DRUG: Oral antibiotics; DRUG: Appropriate intravenous and/or oral antibiotics
- start date: 2026-10-21
- start date type: ACTUAL
- primary completion date: 2027-09-01
- has results: false
- data source: ClinicalTrials.gov
- data processed: 2026-10-29T09:00:05
- modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters

Topics: [Infectious Disease, Vaccines & Antimicrobial Resistance](https://space-kitty.com/topics/infectious-disease-amr)

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