# Biology of Aging & Longevity Domain: Advanced Medicine · 306 papers indexed · newest 2026-10-28 Hallmarks of aging, senolytics, epigenetic clocks, partial reprogramming, mTOR and other geroprotective interventions. Key concepts: aging, epigenetic clock, senescence ## Most influential - **[Hallmarks of aging: An expanding universe](https://space-kitty.com/papers/doi:10.1016/j.cell.2022.11.001)**. Carlos López-Otı́n, Marı́a A. Blasco, Linda Partridge et al. · 2023 · Cell (doi:10.1016/j.cell.2022.11.001 · 6,534 citations). Source: - **[The Hallmarks of Aging](https://space-kitty.com/papers/doi:10.1016/j.cell.2013.05.039)**. Carlos López-Otı́n, Marı́a A. Blasco, Linda Partridge et al. · 2013 · Cell (doi:10.1016/j.cell.2013.05.039 · 14,978 citations). Source: - **[DNA methylation age of human tissues and cell types](https://space-kitty.com/papers/doi:10.1186/gb-2013-14-10-r115)**. Horvath S · 2013 · Genome biology (doi:10.1186/gb-2013-14-10-r115 · 5,694 citations). Source: > Background It is not yet known whether DNA methylation levels can be used to accurately predict age across a broad spectrum of human tissues and cell types, nor whether the resulting age prediction is a biologically meaningful measure. Results I developed a multi-tissue predictor of age that allows one to estimate the DNA methylation age of most tissues and cell types. The predictor, which is freely available, was developed using 8,000 samples from 82 Illumina DNA methylation array datasets, encompassing 51 healthy tissues and cell types. I found that DNA methylation age has the following prop… > _Abstract excerpt by Horvath S, CC-BY, https://doi.org/10.1186/gb-2013-14-10-r115; truncated._ - **[Hallmarks of Cellular Senescence](https://space-kitty.com/papers/doi:10.1016/j.tcb.2018.02.001)**. Alejandra Hernandez‐Segura, Jamil Nehme, Marco Demaria · 2018 · Trends in Cell Biology (doi:10.1016/j.tcb.2018.02.001 · 2,597 citations). Source: - **[SARS-CoV-2 is associated with changes in brain structure in UK Biobank](https://space-kitty.com/papers/doi:10.1038/s41586-022-04569-5)**. Gwenaëlle Douaud, Soojin Lee, Fidel Alfaro‐Almagro et al. · 2022 · Nature (doi:10.1038/s41586-022-04569-5 · 1,645 citations). Source: > . However, it remains unknown whether the impact of SARS-CoV-2 infection can be detected in milder cases, and whether this can reveal possible mechanisms contributing to brain pathology. Here we investigated brain changes in 785 participants of UK Biobank (aged 51-81 years) who were imaged twice using magnetic resonance imaging, including 401 cases who tested positive for infection with SARS-CoV-2 between their two scans-with 141 days on average separating their diagnosis and the second scan-as well as 384 controls. The availability of pre-infection imaging data reduces the likelihood of pre-e… > _Abstract excerpt by Gwenaëlle Douaud et al., CC-BY, https://doi.org/10.1038/s41586-022-04569-5; truncated._ - **[The Achilles' heel of senescent cells: from transcriptome to senolytic drugs](https://space-kitty.com/papers/doi:10.1111/acel.12344)**. Zhu Y, Tchkonia T, Pirtskhalava T et al. · 2015 · Aging cell (doi:10.1111/acel.12344 · 2,112 citations). Source: > The healthspan of mice is enhanced by killing senescent cells using a transgenic suicide gene. Achieving the same using small molecules would have a tremendous impact on quality of life and the burden of age-related chronic diseases. Here, we describe the rationale for identification and validation of a new class of drugs termed senolytics, which selectively kill senescent cells. By transcript analysis, we discovered increased expression of pro-survival networks in senescent cells, consistent with their established resistance to apoptosis. Using siRNA to silence expression of key nodes of this… > _Abstract excerpt by Zhu Y et al., CC-BY, https://doi.org/10.1111/acel.12344; truncated._ - **[A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues](https://space-kitty.com/papers/doi:10.1038/s41467-022-32552-1)**. Saul D, Kosinsky RL, Atkinson EJ et al. · 2022 · Nature communications (doi:10.1038/s41467-022-32552-1 · 1,042 citations). Source: > Although cellular senescence drives multiple age-related co-morbidities through the senescence-associated secretory phenotype, in vivo senescent cell identification remains challenging. Here, we generate a gene set (SenMayo) and validate its enrichment in bone biopsies from two aged human cohorts. We further demonstrate reductions in SenMayo in bone following genetic clearance of senescent cells in mice and in adipose tissue from humans following pharmacological senescent cell clearance. We next use SenMayo to identify senescent hematopoietic or mesenchymal cells at the single cell level from … > _Abstract excerpt by Saul D et al., CC-BY, https://doi.org/10.1038/s41467-022-32552-1; truncated._ - **[Cellular senescence mediates fibrotic pulmonary disease](https://space-kitty.com/papers/doi:10.1038/ncomms14532)**. Schafer MJ, White TA, Iijima K et al. · 2017 · Nature communications (doi:10.1038/ncomms14532 · 1,435 citations). Source: > Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by interstitial remodelling, leading to compromised lung function. Cellular senescence markers are detectable within IPF lung tissue and senescent cell deletion rejuvenates pulmonary health in aged mice. Whether and how senescent cells regulate IPF or if their removal may be an efficacious intervention strategy is unknown. Here we demonstrate elevated abundance of senescence biomarkers in IPF lung, with p16 expression increasing with disease severity. We show that the secretome of senescent fibroblasts, which are selectively … > _Abstract excerpt by Schafer MJ et al., CC-BY, https://doi.org/10.1038/ncomms14532; truncated._ - **[Mitochondrial dysfunction in cell senescence and aging](https://space-kitty.com/papers/doi:10.1172/jci158447)**. Satomi Miwa, Sonu Kashyap, Eduardo N. Chini et al. · 2022 · Journal of Clinical Investigation (doi:10.1172/jci158447 · 1,060 citations). Source: > Mitochondrial dysfunction and cell senescence are hallmarks of aging and are closely interconnected. Mitochondrial dysfunction, operationally defined as a decreased respiratory capacity per mitochondrion together with a decreased mitochondrial membrane potential, typically accompanied by increased production of oxygen free radicals, is a cause and a consequence of cellular senescence and figures prominently in multiple feedback loops that induce and maintain the senescent phenotype. Here, we summarize pathways that cause mitochondrial dysfunction in senescence and aging and discuss the major c… > _Abstract excerpt by Satomi Miwa et al., CC-BY, https://doi.org/10.1172/jci158447; truncated._ - **[Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease](https://space-kitty.com/papers/doi:10.1016/j.ebiom.2019.08.069)**. Hickson LJ, Langhi Prata LGP, Bobart SA et al. · 2019 · EBioMedicine (doi:10.1016/j.ebiom.2019.08.069 · 1,119 citations). Source: > Background Senescent cells, which can release factors that cause inflammation and dysfunction, the senescence-associated secretory phenotype (SASP), accumulate with ageing and at etiological sites in multiple chronic diseases. Senolytics, including the combination of Dasatinib and Quercetin (D + Q), selectively eliminate senescent cells by transiently disabling pro-survival networks that defend them against their own apoptotic environment. In the first clinical trial of senolytics, D + Q improved physical function in patients with idiopathic pulmonary fibrosis (IPF), a fatal senescence-associa… > _Abstract excerpt by Hickson LJ et al., CC-BY, https://doi.org/10.1016/j.ebiom.2019.08.069; truncated._ - **[Autophagy in healthy aging and disease](https://space-kitty.com/papers/doi:10.1038/s43587-021-00098-4)**. Yahyah Aman, Tomas Schmauck‐Medina, Malene Hansen et al. · 2021 · Nature Aging (doi:10.1038/s43587-021-00098-4 · 1,313 citations). Source: - **[International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines](https://space-kitty.com/papers/doi:10.1007/s12603-021-1665-8)**. Míkel Izquierdo, Reshma Aziz Merchant, John Edward Morley et al. · 2021 · The journal of nutrition health & aging (doi:10.1007/s12603-021-1665-8 · 1,245 citations). Source: > The human ageing process is universal, ubiquitous and inevitable. Every physiological function is being continuously diminished. There is a range between two distinct phenotypes of ageing, shaped by patterns of living - experiences and behaviours, and in particular by the presence or absence of physical activity (PA) and structured exercise (i.e., a sedentary lifestyle). Ageing and a sedentary lifestyle are associated with declines in muscle function and cardiorespiratory fitness, resulting in an impaired capacity to perform daily activities and maintain independent functioning. However, in th… > _Abstract excerpt by Míkel Izquierdo et al., CC-BY, https://doi.org/10.1007/s12603-021-1665-8; truncated._ - **[Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study](https://space-kitty.com/papers/doi:10.1016/j.ebiom.2018.12.052)**. Justice JN, Nambiar AM, Tchkonia T et al. · 2019 · EBioMedicine (doi:10.1016/j.ebiom.2018.12.052 · 1,030 citations). Source: > Background Cellular senescence is a key mechanism that drives age-related diseases, but has yet to be targeted therapeutically in humans. Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal cellular senescence-associated disease. Selectively ablating senescent cells using dasatinib plus quercetin (DQ) alleviates IPF-related dysfunction in bleomycin-administered mice. Methods A two-center, open-label study of intermittent DQ (D:100 mg/day, Q:1250 mg/day, three-days/week over three-weeks) was conducted in participants with IPF (n = 14) to evaluate feasibility of implementing a senolytic … > _Abstract excerpt by Justice JN et al., CC-BY, https://doi.org/10.1016/j.ebiom.2018.12.052; truncated._ - **[Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging](https://space-kitty.com/papers/doi:10.1016/j.cell.2013.11.037)**. Ana P. Gomes, Nathan L. Price, Alvin J. Y. Ling et al. · 2013 · Cell (doi:10.1016/j.cell.2013.11.037 · 1,478 citations). Source: - **[Cellular senescence: the good, the bad and the unknown](https://space-kitty.com/papers/doi:10.1038/s41581-022-00601-z)**. Weijun Huang, LaTonya J. Hickson, Alfonso Eirin et al. · 2022 · Nature Reviews Nephrology (doi:10.1038/s41581-022-00601-z · 1,147 citations). Source: ## Newest - **[A Bi-Adjuvant Senolytic Nanovaccine Modulating Dendritic Cell Senescence Ameliorates Aging-Related Metabolic Dysfunction](https://space-kitty.com/papers/doi:10.1002/advs.78545)**. Song Q, Du X, Dong W et al. · 2026 · Advanced science (Weinheim, Baden-Wurttemberg, Germany) (doi:10.1002/advs.78545). Source: - **[How Robust Are Prognostic Radiomic Features? Comparing Selection Techniques on Pooled Glioblastoma Cohorts](https://space-kitty.com/papers/arxiv:2610.26095)**. Yannick Sodonougbo, Marlene Schnieders, Alexia Rizoudis et al. · 2026 (arXiv:2610.26095). Source: - **[Hallmarks of aging in systemic sclerosis: implications for pathogenesis, multimorbidity, and therapeutic development](https://space-kitty.com/papers/doi:10.1016/j.ero.2026.100256)**. Iacovantuono M, Hukara A, Sauer GM et al. · 2026 · EULAR rheumatology open (doi:10.1016/j.ero.2026.100256). Source: - **[Brain Age Gap Progression in Individuals at Risk for Neurodegeneration](https://space-kitty.com/papers/arxiv:2610.18794)**. Jason Scheffel, Saurabh Sihag · 2026 (arXiv:2610.18794). Source: - **[Deep learning-based virtual perturbation reveals increasing heterogeneity of gene regulatory responses with aging](https://space-kitty.com/papers/arxiv:2610.19029)**. Yongjian He, Julia Hanna Haddad Guez, Xu-Wen Wang et al. · 2026 (arXiv:2610.19029). Source: - **[Myelination and Remyelination in Peripheral Nerve Injury: Mechanisms, Regulation, and Therapeutic Perspectives](https://space-kitty.com/papers/doi:10.1002/mco2.71019)**. Huang LX, Sun T, Zhao YB et al. · 2026 · MedComm (doi:10.1002/mco2.71019). Source: - **[Association of Sex Hormone-Binding Globulin with Glycated Hemoglobin and Multidimensional Biomarker Structure in Reproductive-Age Women: An Analysis Based on NHANES 2021--2023](https://space-kitty.com/papers/arxiv:2610.37675)**. Ruilin Miao · 2026 (arXiv:2610.37675). Source: - **[Application of CAR-T cell therapy in orthopedics: From bone malignancies to non-malignant musculoskeletal disorders](https://space-kitty.com/papers/doi:10.1016/j.jot.2026.101235)**. Que Y, Xie X, Xie W et al. · 2026 · Journal of orthopaedic translation (doi:10.1016/j.jot.2026.101235). Source: - **[p53 wild-type/low c-Myc-expressing ONS76 pediatric medulloblastoma cells become senescent after gamma-irradiation and can be eliminated by senolytic substances](https://space-kitty.com/papers/doi:10.1038/s41420-026-03404-4)**. Sonntag J, Preugschas RL, Jazmati D et al. · 2026 · Cell death discovery (doi:10.1038/s41420-026-03404-4). Source: - **[Toward Reliable Patient-Specific Aortic Strain Mapping from 4D CTA: Validation, Spectral Structure, and Clinical Potential](https://space-kitty.com/papers/arxiv:2610.10913)**. Tricia Lobo, Wensi Wu, Harold I. Litt et al. · 2026 · PubMed (arXiv:2610.10913). 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