AlphaPulldown-a python package for protein-protein interaction screens using AlphaFold-Multimer

Abstract

Summary The artificial intelligence-based structure prediction program AlphaFold-Multimer enabled structural modelling of protein complexes with unprecedented accuracy. Increasingly, AlphaFold-Multimer is also used to discover new protein-protein interactions (PPIs). Here, we present AlphaPulldown, a Python package that streamlines PPI screens and high-throughput modelling of higher-order oligomers using AlphaFold-Multimer. It provides a convenient command-line interface, a variety of confidence scores and a graphical analysis tool. Availability and implementation AlphaPulldown is freely available at https://www.embl-hamburg.de/AlphaPulldown. Supplementary information Supplementary note is available at Bioinformatics online.

Abstract of "AlphaPulldown-a python package for protein-protein interaction screens using AlphaFold-Multimer" by Yu D, Chojnowski G, Rosenthal M et al., https://doi.org/10.1093/bioinformatics/btac749, used under its Creative Commons Attribution license (CC-BY); markup removed, otherwise unmodified.