AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models
Mihály Váradi, Stephen Anyango, Mandar Deshpande, Sreenath Sasidharan Nair, Cindy Natassia, Galabina Yordanova, David Yu Yuan, Oana Stroe, Gemma Wood, Agata Laydon, Augustin Žídek, Tim Green, Kathryn Tunyasuvunakool, Stig Petersen, John Jumper, Ellen Clancy, Richard R. Green, Ankur Vora, Mira Lutfi, Michael Figurnov, Andrew Cowie, Nicole Hobbs, Pushmeet Kohli, Gerard J. Kleywegt, Ewan Birney, and 2 more
Abstract
The AlphaFold Protein Structure Database (AlphaFold DB, https://alphafold.ebi.ac.uk) is an openly accessible, extensive database of high-accuracy protein-structure predictions. Powered by AlphaFold v2.0 of DeepMind, it has enabled an unprecedented expansion of the structural coverage of the known protein-sequence space. AlphaFold DB provides programmatic access to and interactive visualization of predicted atomic coordinates, per-residue and pairwise model-confidence estimates and predicted aligned errors. The initial release of AlphaFold DB contains over 360,000 predicted structures across 21 model-organism proteomes, which will soon be expanded to cover most of the (over 100 million) representative sequences from the UniRef90 data set.
Abstract of "AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models" by Mihály Váradi, Stephen Anyango, Mandar Deshpande et al., https://doi.org/10.1093/nar/gkab1061, used under its Creative Commons Attribution license (CC-BY); markup removed, otherwise unmodified.
Record
- Archive ID
- doi:10.1093/nar/gkab1061
- Published
- Oct 19, 2021
- Venue
- Nucleic Acids Research
- DOI
- 10.1093/nar/gkab1061
- PubMed
- 34791371
- PMC
- PMC8728224
- Categories
- Protein Structure and Dynamics
- License
- cc-by
- Provenance
- openalex+europepmc