Mutanome Engineered RNA Immunotherapy: Towards Patient-Centered Tumor Vaccination

Abstract

Advances in nucleic acid sequencing technologies have revolutionized the field of genomics, allowing the efficient targeting of mutated neoantigens for personalized cancer vaccination. Due to their absence during negative selection of T cells and their lack of expression in healthy tissue, tumor mutations are considered as optimal targets for cancer immunotherapy. Preclinical and early clinical data suggest that synthetic mRNA can serve as potent drug format allowing the cost efficient production of highly efficient vaccines in a timely manner. In this review, we describe a process, which integrates next generation sequencing based cancer mutanome mapping, in silico target selection and prioritization approaches, and mRNA vaccine manufacturing and delivery into a process we refer to as MERIT (mutanome engineered RNA immunotherapy).

Abstract of "Mutanome Engineered RNA Immunotherapy: Towards Patient-Centered Tumor Vaccination" by Mathias Vormehr, Barbara Schrörs, Sebastian Boegel et al., https://doi.org/10.1155/2015/595363, used under its Creative Commons Attribution license (CC-BY); markup removed, otherwise unmodified.