Advances in saRNA Vaccine Research against Emerging/Re-Emerging Viruses

Abstract

Although conventional vaccine approaches have proven to be successful in preventing infectious diseases in past decades, for vaccine development against emerging/re-emerging viruses, one of the main challenges is rapid response in terms of design and manufacture. mRNA vaccines can be designed and produced within days, representing a powerful approach for developing vaccines. Furthermore, mRNA vaccines can be scaled up and may not have the risk of integration. mRNA vaccines are roughly divided into non-replicating mRNA vaccines and self-amplifying RNA (saRNA) vaccines. In this review, we provide an overview of saRNA vaccines, and discuss future directions and challenges in advancing this promising vaccine platform to combat emerging/re-emerging viruses.

Abstract of "Advances in saRNA Vaccine Research against Emerging/Re-Emerging Viruses" by Liu Y, Li Y, Hu Q, https://doi.org/10.3390/vaccines11071142, used under its Creative Commons Attribution license (CC-BY); markup removed, otherwise unmodified.