Hierarchical Community Structure of the Adult Drosophila Connectome Reveals Conserved Circuit Archetypes

Abstract

The community structure of connectomes supports functional specialization, adaptability, and cost-efficient wiring. However, little is known about communities in connectomes mapped at the level of individual neurons and synapses. Here, we analyze a whole-brain Drosophila adult connectome using a nested stochastic blockmodel to uncover its hierarchical community structure. Most of the roughly 1500 fine-scale communities–the smallest, and best resolved level of the hierarchy– are spatially compact, mostly assortative, and aligned with biological features. Nonetheless, we find evidence of nonassortative communities, spatially co-localized within the optic lobe and vision-processing pathways. Seeking “functional primitives”–small circuits with functionally narrow feature profiles–we use data-driven clustering to group communities into 45 archetypical meta-clusters based on their spatial, functional, and molecular properties, revealing modular building blocks from which larger, functionally diverse communities are composed. This work advances our understanding of how structure and function are organized in the fruit fly brain and highlights the value of statistical network models in interpreting nanoscale connectomes.

Abstract of "Hierarchical Community Structure of the Adult Drosophila Connectome Reveals Conserved Circuit Archetypes" by Richard F. Betzel, Osmar Del Rio, Nathan Labora et al., https://doi.org/10.64898/2025.12.10.689094, used under its Creative Commons Attribution license (CC-BY-ND); markup removed, otherwise unmodified.