Study of Tumor Tissue Testing in Selecting Treatment for Patients With Metastatic or Locally Advanced Colorectal Cancer

Brief summary

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors select the best treatment for patients and predict their response to treatment. PURPOSE: This randomized phase II/III trial is studying how well tumor tissue testing works in selecting treatment for patients with metastatic or locally advanced colorectal cancer.

Source: ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters. Not a U.S. Government endorsement.

Trial details

status

COMPLETED

phase

PHASE2, PHASE3

study type

INTERVENTIONAL

enrollment

3240

sponsor

Medical Research Council

conditions

Colorectal Cancer

interventions

BIOLOGICAL: bevacizumab; BIOLOGICAL: cetuximab; DRUG: fluorouracil; DRUG: irinotecan hydrochloride; DRUG: leucovorin calcium; DRUG: oxaliplatin; GENETIC: RNA analysis; GENETIC: cytogenetic analysis; GENETIC: fluorescence in situ hybridization; GENETIC: gene expression analysis

start date

2009-07-01

primary completion date

2010-08-01

has results

false

data source

ClinicalTrials.gov

data processed

2026-10-29T09:00:05

modifications

selected fields only; whitespace normalized; brief summary truncated to 2,000 characters