Combination Immunotherapy Targeting Sarcomas

Shenzhen Geno-Immune Medical Institute

Source: ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters. Not a U.S. Government endorsement.

Brief summary

The aim of this clinical trial is to assess the feasibility, safety and efficacy of a combination low dose chemotherapy and immunotherapy in patients who have sarcoma that is relapsed or late staged. Another goal of the study is to assess the safety and efficacy of the therapy that combines multiple CAR T cells followed by sarcoma vaccines.

Source: ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters. Not a U.S. Government endorsement.

Trial details

status
NOT_YET_RECRUITING
phase
PHASE1, PHASE2
study type
INTERVENTIONAL
enrollment
20
sponsor
Shenzhen Geno-Immune Medical Institute
conditions
Sarcoma; Osteoid Sarcoma; Ewing Sarcoma
interventions
BIOLOGICAL: Multiple sarcoma-specific CAR-T cells and sarcoma vaccines
start date
2027-07-01
start date type
ESTIMATED
primary completion date
2029-05-31
has results
false
data source
ClinicalTrials.gov
data processed
2026-10-29T09:00:05
modifications
selected fields only; whitespace normalized; brief summary truncated to 2,000 characters

Record

Archive ID
nct:NCT04433221
Published
Jun 16, 2020
Updated
Aug 26, 2026
Venue
ClinicalTrials.gov
ClinicalTrials.gov
NCT04433221
Categories
Sarcoma, Osteoid Sarcoma, Ewing Sarcoma
License
ClinicalTrials.gov terms (attribution, processing date, modifications noted)
Provenance
clinicaltrials

Topics