Infectious Disease, Vaccines & Antimicrobial Resistance
New antibiotic classes and AI-discovered antibiotics, phage therapy, long-acting HIV prevention and next-generation vaccines.
Most influential
- Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis
BACKGROUND: Antimicrobial resistance (AMR) poses a major threat to human health around the world. Previous publications have estimated the effect of AMR on incidence, deaths, hospital length of stay, and health-care costs for specific pathogen-drug combinations in select locations. To our knowledge, this study presents the most comprehensive estimates of AMR…
Abstract excerpt by Christopher J L Murray et al., CC-BY, https://doi.org/10.1016/s0140-6736(21)02724-0; truncated.
Review16,288 citationsdoi:10.1016/s0140-6736(21)02724-0 - Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050
BACKGROUND: Antimicrobial resistance (AMR) poses an important global health challenge in the 21st century. A previous study has quantified the global and regional burden of AMR for 2019, followed with additional publications that provided more detailed estimates for several WHO regions by country. To date, there have been no studies that produce comprehensiv…
Abstract excerpt by Mohsen Naghavi et al., CC-BY, https://doi.org/10.1016/s0140-6736(24)01867-1; truncated.
Article3,903 citationsdoi:10.1016/s0140-6736(24)01867-1 - Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019
BACKGROUND: Reducing the burden of death due to infection is an urgent global public health priority. Previous studies have estimated the number of deaths associated with drug-resistant infections and sepsis and found that infections remain a leading cause of death globally. Understanding the global burden of common bacterial pathogens (both susceptible and …
Abstract excerpt by Kevin Shunji Ikuta et al., CC-BY, https://doi.org/10.1016/s0140-6736(22)02185-7; truncated.
Article2,232 citationsdoi:10.1016/s0140-6736(22)02185-7 - The WHO Bacterial Priority Pathogens List 2024: a prioritisation study to guide research, development, and public health strategies against antimicrobial resistance
BACKGROUND: The 2017 WHO Bacterial Priority Pathogens List (BPPL) has been instrumental in guiding global policy, research and development, and investments to address the most urgent threats from antibiotic-resistant pathogens, and it is a key public health tool for the prevention and control of antimicrobial resistance (AMR). Since its release, at least 13 …
Abstract excerpt by Hatim F. Sati et al., CC-BY, https://doi.org/10.1016/s1473-3099(25)00118-5; truncated.
Article947 citationsdoi:10.1016/s1473-3099(25)00118-5 - Open-access bacterial population genomics: BIGSdb software, the PubMLST.org website and their applications
The PubMLST.org website hosts a collection of open-access, curated databases that integrate population sequence data with provenance and phenotype information for over 100 different microbial species and genera. Although the PubMLST website was conceived as part of the development of the first multi-locus sequence typing (MLST) scheme in 1998 the software it…
Abstract excerpt by Jolley KA et al., CC-BY, https://doi.org/10.12688/wellcomeopenres.14826.1; truncated.
Article3,086 citationsdoi:10.12688/wellcomeopenres.14826.1 - Antimicrobial resistance: Impacts, challenges, and future prospects
Antimicrobial resistance (AMR) is a critical global health issue driven by antibiotic misuse and overuse in various sectors, leading to the emergence of resistant microorganisms. The history of AMR dates back to the discovery of penicillin, with the rise of multidrug-resistant pathogens posing significant challenges to healthcare systems worldwide. The misus…
Abstract excerpt by Sirwan Khalid Ahmed et al., CC-BY, https://doi.org/10.1016/j.glmedi.2024.100081; truncated.
Article1,252 citationsdoi:10.1016/j.glmedi.2024.100081 - CARD 2020: antibiotic resistome surveillance with the comprehensive antibiotic resistance database
The Comprehensive Antibiotic Resistance Database (CARD; https://card.mcmaster.ca) is a curated resource providing reference DNA and protein sequences, detection models and bioinformatics tools on the molecular basis of bacterial antimicrobial resistance (AMR). CARD focuses on providing high-quality reference data and molecular sequences within a controlled v…
Abstract excerpt by Alcock BP et al., CC-BY, https://doi.org/10.1093/nar/gkz935; truncated.
Article2,855 citationsdoi:10.1093/nar/gkz935 - Antimicrobial Resistance in ESKAPE PathogensReview2,102 citationsdoi:10.1128/cmr.00181-19
- Antimicrobial Resistance: A Growing Serious Threat for Global Public Health
Antibiotics are among the most important discoveries of the 20th century, having saved millions of lives from infectious diseases. Microbes have developed acquired antimicrobial resistance (AMR) to many drugs due to high selection pressure from increasing use and misuse of antibiotics over the years. The transmission and acquisition of AMR occur primarily vi…
Abstract excerpt by Salam MA et al., CC-BY, https://doi.org/10.3390/healthcare11131946; truncated.
Review1,428 citationsdoi:10.3390/healthcare11131946 - Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis
Background Infections due to antibiotic-resistant bacteria are threatening modern health care. However, estimating their incidence, complications, and attributable mortality is challenging. We aimed to estimate the burden of infections caused by antibiotic-resistant bacteria of public health concern in countries of the EU and European Economic Area (EEA) in …
Abstract excerpt by Cassini A et al., CC-BY, https://doi.org/10.1016/s1473-3099(18)30605-4; truncated.
Article2,136 citationsdoi:10.1016/s1473-3099(18)30605-4 - Antimicrobial Resistance (AMR)
Antimicrobial resistance (AMR) has now emerged as a chronic public health problem globally, with the forecast of 10 million deaths per year globally by 2050. AMR occurs when viruses, bacteria, fungi and parasites do not respond to antimicrobial treatments in humans and animals, thus allowing the survival of the microorganism within the host. The prominent ca…
Abstract excerpt by Ka Wah Kelly Tang et al., CC-BY, https://doi.org/10.3389/bjbs.2023.11387; truncated.
Review1,038 citationsdoi:10.3389/bjbs.2023.11387 - Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study
Background We have previously estimated that respiratory syncytial virus (RSV) was associated with 22% of all episodes of (severe) acute lower respiratory infection (ALRI) resulting in 55 000 to 199 000 deaths in children younger than 5 years in 2005. In the past 5 years, major research activity on RSV has yielded substantial new data from developing countri…
Abstract excerpt by Shi T et al., CC-BY, https://doi.org/10.1016/s0140-6736(17)30938-8; truncated.
Review1,997 citationsdoi:10.1016/s0140-6736(17)30938-8 - AMRFinderPlus and the Reference Gene Catalog facilitate examination of the genomic links among antimicrobial resistance, stress response, and virulence
Antimicrobial resistance (AMR) is a significant public health threat. With the rise of affordable whole genome sequencing, in silico approaches to assessing AMR gene content can be used to detect known resistance mechanisms and potentially identify novel mechanisms. To enable accurate assessment of AMR gene content, as part of a multi-agency collaboration, N…
Abstract excerpt by Feldgarden M et al., CC-BY, https://doi.org/10.1038/s41598-021-91456-0; truncated.
Article1,516 citationsdoi:10.1038/s41598-021-91456-0 - Will 10 Million People Die a Year due to Antimicrobial Resistance by 2050?
Points• A recent high profile report estimates that, by 2050, 10 million people will die every year due to antimicrobial resistance (AMR) unless a global response to the problem of AMR is mounted.• There is undoubtedly a large clinical and public health burden associated with AMR, but it is challenging to quantify the associated excess morbidity and mortalit…
Abstract excerpt by Marlieke E.A. de Kraker et al., CC-BY, https://doi.org/10.1371/journal.pmed.1002184; truncated.
Article1,608 citationsdoi:10.1371/journal.pmed.1002184 - Access to effective antimicrobials: a worldwide challengeReview1,461 citationsdoi:10.1016/s0140-6736(15)00474-2
Newest work
- Evaluation of the Effect of Antibiotic Prophylaxis During Lumpectomy for Breast Cancer: Prospective Randomised Double-blind Noninferiority Study of Placebo vs CefazolinClinical trialNCT07898943
- Health Diplomacy in Limited-Resource Settings in Africa: What It Takes Towards a Realistic, Resilient and Equitable Agenda?Reviewdoi:10.1002/puh2.70381
- Subverting colonization resistance: <i>Salmonella</i> pathogenesis at the interface of microbiota, metabolism and inflammasomeReviewdoi:10.1080/21505594.2026.2745323
- The impact of prophylactic azithromycin on the developing preterm gut microbiome and resistomeArticledoi:10.1080/19490976.2026.2748147
- Effects on health and antioxidant status of oral supplementation of hazelnut skin extract in dairy calves with neonatal diarrhea: a randomized clinical trial in hospitalized patientsArticledoi:10.1080/01652176.2026.2691428
- Genomic characterization of <i>Aliarcobacter</i> spp. from livestock in commercial and smallholder farms and from children in Ghana and TanzaniaArticledoi:10.1016/j.onehlt.2026.101616
- High willingness to receive a vaccine for gonorrhoea prevention among gay, bisexual, queer, and other sexuality diverse men, and non-binary people in AustraliaArticledoi:10.1016/j.vaccine.2026.129233
- Extended spectrum beta lactamases and carbapenemase-producing <i>Escherichia coli</i> in humans, animals and the environment in East Africa: a scoping reviewReviewdoi:10.1016/j.onehlt.2026.101606
- Dietary licorice improves carcass yield, hepatocellular protection, gut health, oxidative status, and cecal bacterial balance in broiler chickensArticledoi:10.1016/j.vas.2026.100892
- Efficacy of Short Course of Intravenous Dexamethasone and Intravenous Immunoglobulin Therapy in Infection-Related Secondary Hemophagocytic Lymphohistiocytosis (isHLH)Clinical trialNCT07861776
Clinical trials
- Effects of Mass Drug Administration of Azithromycin on Mortality and Other Outcomes Among 1-11 Month Old Infants in MaliClinical trialNCT04424511
- Randomised Evaluation of COVID-19 TherapyClinical trialNCT04381936
- Azithromycin-Prevention in Labor Use Study (A-PLUS)Clinical trialNCT03871491
- Sanitation, Water, and Instruction in Face-washing for Trachoma I/IIClinical trialNCT02754583
- Selective Decontamination of the Digestive Tract in Intensive Care Unit PatientsClinical trialNCT02389036
- Azithromycin Prophylaxis for PRElabor CEsarean DElivery TrialClinical trialNCT06605118
- Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired PneumoniaClinical trialNCT02735707
- Reducing Mortality in Adults With Advanced HIV Disease (REVIVE)Clinical trialNCT05580666