A Study to Compare Different Antibiotics and Different Modes of Fluid Treatment for Children With Severe Pneumonia

Brief summary

Pneumonia is one of the top causes of death in children aged below 5. More than 10% of children with severe pneumonia die. We are not sure that the currently recommended antibiotics used in children with pneumonia are the most effective. No studies have been carried out to find out whether children with pneumonia should be given intravenous (IV) fluids or nasogastric (NG) feeds. The SEARCH trial aims to find out which antibiotics and modes of feeding are the most effective in treating children with severe pneumonia and therefore helping reduce mortality.

Source: ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters. Not a U.S. Government endorsement.

Trial details

acronym

SEARCH

status

COMPLETED

phase

PHASE3

study type

INTERVENTIONAL

enrollment

4392

sponsor

University of Oxford

conditions

Pneumonia

interventions

DRUG: Benzyl penicillin; DRUG: Gentamicin Sulfate; DRUG: Ceftriaxone; DRUG: Amoxicillin Clavulanate; OTHER: Intravenous fluid; OTHER: Nasogastric feeds; DRUG: Ampicillin

start date

2019-08-19

start date type

ACTUAL

primary completion date

2024-04-05

has results

false

data source

ClinicalTrials.gov

data processed

2026-10-29T09:00:05

modifications

selected fields only; whitespace normalized; brief summary truncated to 2,000 characters