Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis
Children's Hospital of Philadelphia
View at source ↗Clinical trial
Source: ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters. Not a U.S. Government endorsement.
Brief summary
The objectives of this multicenter pragmatic clinical trial are to compare the effectiveness and relative safety of balanced fluid resuscitation versus 0.9% "normal" saline in children with septic shock, including whether balanced fluid resuscitation can reduce progression of kidney injury.
Source: ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters. Not a U.S. Government endorsement.
Trial details
- acronym
- PRoMPT BOLUS
- status
- COMPLETED
- phase
- PHASE3
- study type
- INTERVENTIONAL
- enrollment
- 9041
- sponsor
- Children's Hospital of Philadelphia
- conditions
- Shock; Septic
- interventions
- DRUG: Lactated Ringer; DRUG: Normal Saline; DRUG: Plasma-lyte
- start date
- 2020-08-25
- start date type
- ACTUAL
- primary completion date
- 2025-12-01
- has results
- false
- data source
- ClinicalTrials.gov
- data processed
- 2026-10-29T09:00:05
- modifications
- selected fields only; whitespace normalized; brief summary truncated to 2,000 characters
Record
- Archive ID
- nct:NCT04102371
- Published
- Sep 25, 2019
- Updated
- Mar 5, 2026
- Venue
- ClinicalTrials.gov
- ClinicalTrials.gov
- NCT04102371
- Categories
- Shock, Septic
- License
- ClinicalTrials.gov terms (attribution, processing date, modifications noted)
- Provenance
- clinicaltrials