Light-Activated Antimicrobial Therapy to Prevent Surgical Site Infections

Brief summary

This is a Phase 3 multi-center, group-randomized, crossover trial to compare nasal antimicrobial photodisinfection therapy (aPDT) with standard of care for prevention of surgical site infections in patients undergoing major elective, urgent, or emergent surgeries in a hospital setting. The main outcomes are to: 1. compare the efficacy, and 2. estimate the safety of applying nasal (aPDT) before surgery in reducing the incidence of SSIs within the initial 30 days after surgery compared to standard of care (SOC). Participants in the intervention group will receive aPDT prior to surgery on the day of surgery. Participants in the control group will receive standard of care surgical site prevention measures prior to surgery.

Source: ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters. Not a U.S. Government endorsement.

Trial details

acronym

LANTERN

status

COMPLETED

phase

PHASE3

study type

INTERVENTIONAL

enrollment

4787

sponsor

Ondine Biomedical Inc.

conditions

Surgical Site Infections; Surgical Wound Infection; Infections; Anti-Infective Agents

interventions

COMBINATION_PRODUCT: nasal antimicrobial photodisinfection therapy

start date

2024-12-27

start date type

ACTUAL

primary completion date

2026-04-03

has results

false

data source

ClinicalTrials.gov

data processed

2026-10-29T09:00:05

modifications

selected fields only; whitespace normalized; brief summary truncated to 2,000 characters