Organoids & Organ-on-Chip
Brain and tissue organoids, assembloids, organ-on-chip platforms and their use in disease modeling and drug testing.
Most influential
- Cerebral organoids model human brain development and microcephalyArticle5,369 citationsdoi:10.1038/nature12517
- Organoid Models and Applications in Biomedical ResearchReview3,515 citationsdoi:10.1159/000433566
- Modeling Development and Disease with OrganoidsReview3,196 citationsdoi:10.1016/j.cell.2016.05.082
- Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
Pancreatic stellate cells (PSCs) differentiate into cancer-associated fibroblasts (CAFs) that produce desmoplastic stroma, thereby modulating disease progression and therapeutic response in pancreatic ductal adenocarcinoma (PDA). However, it is unknown whether CAFs uniformly carry out these tasks or if subtypes of CAFs with distinct phenotypes in PDA exist. …
Abstract excerpt by Öhlund D et al., CC-BY, https://doi.org/10.1084/jem.20162024; truncated.
Article2,274 citationsdoi:10.1084/jem.20162024 - Organogenesis in a dish: Modeling development and disease using organoid technologiesReview2,930 citationsdoi:10.1126/science.1247125
- Human organoids: model systems for human biology and medicineReview2,186 citationsdoi:10.1038/s41580-020-0259-3
- SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion
The B.1.617.2 (Delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified in the state of Maharashtra in late 2020 and spread throughout India, outcompeting pre-existing lineages including B.1.617.1 (Kappa) and B.1.1.7 (Alpha) 1 . In vitro, B.1.617.2 is sixfold less sensitive to serum neutralizing antibodies from reco…
Abstract excerpt by Mlcochova P et al., CC-BY, https://doi.org/10.1038/s41586-021-03944-y; truncated.
Article1,142 citationsdoi:10.1038/s41586-021-03944-y - Organoid Models of Human and Mouse Ductal Pancreatic CancerArticle2,149 citationsdoi:10.1016/j.cell.2014.12.021
- Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV ExposureArticle2,127 citationsdoi:10.1016/j.cell.2016.04.032
- Organoids in cancer researchReview1,787 citationsdoi:10.1038/s41568-018-0007-6
- Generation of cerebral organoids from human pluripotent stem cellsArticle1,807 citationsdoi:10.1038/nprot.2014.158
- Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesisArticle1,627 citationsdoi:10.1038/nature15695
- Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver
Despite the enormous replication potential of the human liver, there are currently no culture systems available that sustain hepatocyte replication and/or function in vitro. We have shown previously that single mouse Lgr5+ liver stem cells can be expanded as epithelial organoids in vitro and can be differentiated into functional hepatocytes in vitro and in v…
Abstract excerpt by Meritxell Huch et al., CC-BY, https://doi.org/10.1016/j.cell.2014.11.050; truncated.
Article1,619 citationsdoi:10.1016/j.cell.2014.11.050 - Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening
Lung cancer shows substantial genetic and phenotypic heterogeneity across individuals, driving a need for personalised medicine. Here, we report lung cancer organoids and normal bronchial organoids established from patient tissues comprising five histological subtypes of lung cancer and non-neoplastic bronchial mucosa as in vitro models representing individu…
Abstract excerpt by Kim M et al., CC-BY, https://doi.org/10.1038/s41467-019-11867-6; truncated.
Article641 citationsdoi:10.1038/s41467-019-11867-6 - In vitro generation of human pluripotent stem cell derived lung organoids
Recent breakthroughs in 3-dimensional (3D) organoid cultures for many organ systems have led to new physiologically complex in vitro models to study human development and disease. Here, we report the step-wise differentiation of human pluripotent stem cells (hPSCs) (embryonic and induced) into lung organoids. By manipulating developmental signaling pathways …
Abstract excerpt by Briana R. Dye et al., CC-BY, https://doi.org/10.7554/elife.05098; truncated.
Article824 citationsdoi:10.7554/elife.05098
Newest work
- Patient-Derived Organoids from cryopreserved tissue can represent clinically relevant tools for drug testing in Biliary CancerArticledoi:10.1016/j.jhepr.2026.102083
- High-fat diet-derived metabolite uridine diphosphate (UDP) impairs epithelial regeneration by P2Y <sub><b>6</b></sub> -receptor signalingArticledoi:10.1080/19490976.2026.2748160
- Wireless bioelectronic control architectures for muscle-powered biohybrid robotic systemsArticledoi:10.1063/5.0339053
- Protocol for fabricating immune-regulatory bone organoids via plant-based bioinksArticledoi:10.1016/j.isci.2026.117866
- Inhibition of WNT signaling sensitizes CRC cells to anti-tumor effects of retinoids: basis for new drug combinations in oncologyArticledoi:10.1080/15384047.2026.2732738
- Human induced pluripotent stem cells and organoid models in space for investigating severe pediatric metabolic and congenital disordersReviewdoi:10.1093/pcmedi/pbag028
- <i>Achyranthes bidentata</i>-functionalized bone organoids enhance bone defect repairArticledoi:10.1016/j.mtbio.2026.103716
- Systematic standardization of organ-on-a-chip under controlled flow conditions: Use case with Caki-1 and A549 cell linesArticledoi:10.1016/j.mex.2026.104172
- Fibroblast-associated TPM2 links cell-matrix remodeling to EMT-Notch signaling and gemcitabine resistance in intrahepatic cholangiocarcinomaArticledoi:10.1080/15384047.2026.2725344
- Engineering high-fidelity bone organoids: Operational classification, multilineage crosstalk, biofabrication evidence, and translational validationArticledoi:10.1016/j.mtbio.2026.103676